Coloring Page Goddess Bastet

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Strong placebo response thwarts painkiller trials

Interesting article, placebo’s as effective as meds.

Drug companies have a problem: they are finding it ever harder to get painkillers through clinical trials. But this isn’t necessarily because the drugs are getting worse. An extensive analysis of trial data1 has found that responses to sham treatments have become stronger over time, making it harder to prove a drug’s advantage over placebo.

The change in response to placebo treatments for pain, discovered by researchers in Canada, holds true only for US clinical trials. “We were absolutely floored when we found out,” says Jeffrey Mogil, who directs the pain-genetics lab at McGill University in Montreal and led the analysis. Simply being in a US trial and receiving sham treatment now seems to relieve pain almost as effectively as many promising new drugs. Mogil thinks that as US trials get longer, larger and more expensive, they may be enhancing participants’ expectations of their effectiveness.

See the entire article here:  http://www.nature.com/news/strong-placebo-response-thwarts-painkiller-trials-1.18511?%3Fftcamp=crm%2Femail%2F%2Fnbe%2FFirstFTEurope%2Fproduct

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What happens in our brain when we practice mindfulness?

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What is #depression? – Helen M. Farrell

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Coloring Page Borzoi Dog

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MSU study finds surprises about drug use

Conducting an economic analysis of drug use is a particularly difficult endeavor, but for Michigan State University professor and economist Siddharth Chandra, it just meant taking a look at the history books.

“You can’t simply go to Wal-Mart and look at the sticker price, and people don’t want to talk to you because drugs are illegal and they think they’ll get in trouble, ” Chandra said. “Our study is the first time the subject of how populations of consumers switch between drugs is being studied with data considered reliable.”1pillst.jpg

To find reliable economic data on drug use, Chandra, also the director of the Asian Studies Center at MSU, had to look back to early 20th century India, when the region was still part of the British Empire.

“One hundred years ago these products were legal. In British India the government was actually selling these things to the public, and they kept meticulous records,” Chandra said.

In his study – the first of its kind – Chandra pored through stacks of 100-year-old ledgers, called Excise Administration Reports, kept by the governments of the various provinces of India. Interpreting these data, he found surprising results about the economics of drug use behaviors. Despite the stark differences in the effects of opium vs. cannabis on the human body, the study shows that users would switch between the two drugs when the price of one went up – in economics, a phenomenon called substitution.

“The time, place and context are different, but the phenomenon is there. You might think consumers would treat them differently,” Chandra said. “But just because the two drugs used are very different, doesn’t mean people won’t switch.”

Opium, used legally to make the pain medicine morphine and illegally to make the drug heroin, is a highly addictive and potent depressant with potentially lethal side effects. Cannabis, also known as marijuana, is a less potent drug that produces a sense of relaxation and euphoria when used, usually through smoking or ingestion. These differences only came into consideration when analyzing cannabis in its weakest form, a drug called bhang, which consumers would not substitute for the more potent opium.

“There are many policy implications for these results,” Chandra said. “Targeting a particular drug with policies and enforcement might backfire.”

Chandra pointed to the epidemic of heroin, a product of opium that is relatively inexpensive and is devastating some communities in the United States.

“Many people know someone who has been affected by heroin – it is a very dangerous drug,” Chandra said. “But prohibiting harmful drugs selectively can be ineffective. Consumers may switch.”

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Yoga may boost your brain power

Yogis may be enjoying a surprising benefit when they unroll their mats and strike a pose. A new study finds that just 20 minutes of hatha yoga stimulates brain function.

Researchers from the University of Illinois at Urbana-Champaign enlisted 30 subjects to take tests of working memory and inhibitory control, two measures of brain function associated with the ability to focus, retain, and use new information, the researchers said.

Subjects who took a single, 20-minute yoga session were significantly faster and more accurate on their tests than subjects who walked or jogged on a treadmill for 20 minutes.
Participants on the treadmill exercised with the goal of maintaining 60 to 70 percent of their maximum heart rate throughout the exercise session. “This range was chosen to replicate previous findings that have shown improved cognitive performance in response to this intensity,” the researchers said.1472891_10151996608469691_438298404_n

“Yoga is an ancient Indian science and way of life that includes not only physical movements and postures but also regulated breathing and meditation,” said study lead Neha Gothe. “The practice involves an active attentional or mindfulness component but its potential benefits have not been thoroughly explored.”

Subjects who practiced yoga performed a 20-minute sequence of seated, standing, and supine yoga postures, with the class ending in a meditative posture and deep breathing.

“It appears that following yoga practice, the participants were better able to focus their mental resources, process information quickly, more accurately and also learn, hold and update pieces of information more effectively than after performing an aerobic exercise bout,” Gothe said.

“The breathing and meditative exercises aim at calming the mind and body and keeping distracting thoughts away while you focus on your body, posture or breath,” she said. “Maybe these processes translate beyond yoga practice when you try to perform mental tasks or day-to-day activities.”

Findings, announced June 5, appear in the Journal of Physical Activity and Health.
A separate study published last month finds that twice-weekly yoga sessions can reduce high blood pressure. In the study, researchers led by Dr. Debbie Cohen of the University of Pennsylvania tracked 58 women and men, aged 38 to 62, for 24 weeks.

Another study published earlier this year in the journal Frontiers in Psychiatry found that the practice may soothe depression and help sleep problems.

Read more:A 20-minute yoga session may boost your brain power – The Denver Post

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